2003 1500 5.3 misfire problems

bandrew1125

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My 2003 1500 with 5.3L started having a ruff idle and I am getting codes po300 and po445. Truck does not have power a lot of the time and sometimes it does not want to shift properly. I noticed it is making a squealing noise from what seems to be around one of the coils.(sounds like belt squealing but on top of engine). Any help would be great. TIA Andy
 
Thanks zora,
I got the po445 code taken care of. I then replaced the spark plugs and wires. I was then given a code for maf sensor, and got that taken care of. Still have misfire issue and squealing noise. Going to try to check for vaccum leaks.
 
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