I had this code on my S-10, and figuring it out was a big pain in the you know what. It could either be the coil, or the ignition module. I would start with the coils, they are cheaper. Once you replace them, make sure to disconnect and reconnect the battery to reset the code, if it still comes up, then change the ignition module. You could also be doing damage to the catalytic converter if you are running the truck. I had to replace mine because we ran it trying to figure out what the problem was, and I know that part alone can run 300 bucks or more, so don't run it if you don't have too.