I've got a 1990 2500 with a 454 (7.4L if you're French - you KNOW what I mean) with fuel injection, a TH400 tranny, 3.73 gears. This thing can tow anything, and I love it! I agree with some posters thinking that if you're worried about mileage drive a Toyota. If I did, the money I saved on gas would have to be spent on psycho therapy - I'd need it when I realized I was driving a Toyota! So it evens out in the end.
That said, I get 10, but have gotten up to 14 on a long road trip (keep it 65 - 70 mph). I'll be driving 10 hours across California this weekend, so I'll be sure to track it again. BTW, anyone complaining about gas prices that are UNDER $4, needs to come out West for a true rip off.